Ti-based robust MOFs in the combined photocatalytic degradation of emerging organic contaminants

Photocatalysis process is a promising technology for environmental remediation. In the continuous search of new heterogeneous photocatalysts, metal–organic frameworks (MOFs) have recently emerged as a new type of photoactive materials for water remediation. Particularly, titanium-based MOFs (Ti-MOFs) are considered one of the most appealing subclass of MOFs due to their promising optoelectronic and photocatalytic properties, high chemical stability, and unique structural features. However, considering the limited information of the reported studies, it is a hard task to determine if real-world water treatment is attainable using Ti-MOF photocatalysts. In this paper, via a screening with several Ti-MOFs, we originally selected and described the potential of a Ti-MOF in the photodegradation of a mixture of relevant Emerging Organic Contaminants (EOCs) in real water. Initially, two challenging drugs (i.e., the β-blocker atenolol (At) and the veterinary antibiotic sulfamethazine (SMT)) and four water stable and photoactive Ti-MOF structures have been rationally selected. From this initial screening, the mesoporous Ti-trimesate MIL-100(Ti) was chosen as the most promising photocatalyst, with higher At or SMT individual photodegradation (100% of At and SMT photodegradation in 2 and 4 h, respectively). Importantly, the safety of the formed by-products from the At and SMT photodegradation was confirmed. Finally, the At and SMT photodegradation capacity of MIL-100(Ti) was confirmed under realistic conditions, by using a mixture of contaminants in tap drinking water (100% of At and SMT photodegradation in 4 h), proven in addition its potential recyclability, which reinforces the potential of MIL-100(Ti) in water remediation.

There is no doubt that pharmaceuticals have efficiently increased life quality and expectancy. However, this exceptional step for humanity has nowadays led to an important environmental issue. Human and veterinary pharmaceuticals, and illicit drugs have been recently defined as Emerging Organic Contaminants (EOCs), being present in biota, sediments, effluents, and surface and ground water 1 . Despite their relatively low concentrations in natural waters (few ng·L −1 -µg·L −1 ), EOCs are of particular concern for several reasons: (1) they have been detected in wastewater treatment plants (WWTPs) and hospitals effluents since these installations are not adapted to eliminate them; (2) many pharmaceuticals have been described recently as endocrine disruptors, raising many questions about risk to the environment and human health 2 ; (3) they can be persistent, and their degradation products can be even more toxic than the parent products 3 , and (4) drug prescription is expected to sharply increase over the coming decades given the human population growth, the aging population and the drug medical coverage expansion. An increasing number of EOCs in the environment call to not only their monitoring and detection, but also, their efficient elimination.
Among the proposed technologies (e.g., ion-exchange, adsorption and flotation, reverse osmosis) 4 , advanced oxidation processes (AOPs; e.g., photocatalysis, Fenton reactions, sulphate radical mediated oxidations) have attracted a great deal of attention for the water treatment due to their simplicity and reproducibility 4,5 . In www.nature.com/scientificreports/ identifying the mesoporous Ti-trimesate MIL-100(Ti) as the most promising photocatalyst. Subsequently, we have identified the formed by-products from the At and SMT photodegradation, considering their potential toxicity, in order to assess the impact of the MIL-100(Ti) treatment on the resulting water quality. Finally, to deeply evaluate the potential application of MIL-100(Ti) in water remediation, a photodegradation study was carried out under realistic conditions (i.e., mixture of contaminants in tap drinking water, in absence of other co-catalyst/additive, without an adsorption equilibrium time) and considering the potential recyclability, which highlights the originality and interest of this work.

Results and discussion
Selection of EOCs. Among the commonly used 100 pharmaceuticals 13 , anti-hypertensive and antibiotic drugs are two of the most consumed groups. Arterial hypertension is one of the main chronic health problems, being extremely prevalent (20%) among the older adult population 14 . β-blockers are among the most consumed drugs used in arterial hypertension treatment 15 . During 2020, the consumption of β-blockers ranged around 24,495 (defined daily doses per 1,000 inhabitants per day) 16 . In particular At, a β-blocker drug primarily used to treat patients suffering from various heart disorders such as high blood pressure, chest pain (angina), migraines, and irregular heartbeats 17 , was ranked the 31st most prescribed drug in United States of America in 2014 18 . In addition, At cannot be fully metabolized by the human body, undergoing incomplete absorption (ca. 90%) and being largely excreted unchanged in the urine [19][20][21] , exponentially increasing its presence in water (from 0.35 to 2.21 mg·L -1 ) 22,23 . Further, the presence of At in water may cause severe toxic effects (e.g., dizziness, feeling tired, depression, chances of heart failure, shortness of breath, and cause bronchospasm), being also accumulated in breast milk, which is related to the immaturity of the renal function of neonate breast-fed infants 17,24 .
On the other hand, because of their importance for human and veterinary medicine, but also because of their persistence, sulfonamides, quinolones and trimethoprim are the most widely detected antibiotics in water 25 . Only in Spain, in 2020 the daily dose of prescribed antibiotics by the public health system were 19 per 1000 inhabitants per day according to the Spanish Agency for Medicines and Health Products. Among the most widely prescribed groups of antibiotics, we can find β-lactams (53.4%), macrolides and lincosamide (11.3%), quinolones (9.8%), tetracycline (8.0%), and sulfonamides and trimethoprim (2.5%) 26 . Regarding the veterinary use of antibiotics, in the European Union, the bestseller antibiotics were tetracyclines (30.4%), β-lactams (26.9%) and sulfonamides (9.2%) 27 . Particularly, the sulfonamide sulfamethazine (SMT), frequently used in pigs and cattle, has been detected in natural environments such as soil or water, ranging from a few ng to tens of mg per liter or kg of soil 28,29 . Large proportions of this compound is excreted unchanged in feces and urine given its incomplete metabolism 30 . Furthermore, the presence of SMT in water is associated with significant risks for humans due to the development of microbial resistances, even at low doses 31 .

Screening of the SMT and At photodegradation and MOF stability. For the efficient removal of
EOCs from water, we have selected 4 Ti-MOFs based on: (1) Ti-oxoclusters with redox and photocatalytic activity that could be exploited in the photodegradation of EOCs 10 , (2) their a priori remarkable hydrolytic stability (mostly tested in pure MilliQ water), (3) their exceptional porosity (see SI, Table S1), in some cases compatible with the SMT and At dimensions (11 × 5 × 5 Å 3 , and 15 × 7 × 5 Å 3 , respectively; estimated by Vesta considering van der Waals radii), and (4) in terms of cost, they could be considered affordable for large scale production in the future 32 36 , based on photo/redox 2D titanium layers and the squarate (SQ, 3,4-dihydroxycyclobut-3-ene-1,2-dionate) as organic linker (see detailed properties in Table S1), with small porosity (~ 4.5 Å; S BET ~ 120 m 2 ·g −1 ) but an exceptional hydrolytic stability.
Interestingly, these results highlight the remarkable ability of the MIL-100(Ti) to remove both EOCs, eliminating 100% of At and SMT in only 2 and 4 h, respectively. The plateau of degradation is reached only after 1 h in all studied materials, except for the continuous At degradation of IEF-11, and SMT and At degradation of MIL-100(Ti) where it took only 2 h. Factors like MOF structure/porosity (pore accessibility, surface, volume, tortuosity, connectivity, particle size, etc.) and nature (ligand, cluster structure, band gap, external surface, etc.) might influence the pharmaceuticals degradation capacity. For instance, compared with the rest of studied Ti-MOFs, the lower accessibility of IEF-11, with a pore and window size of 4.5 Å, might hamper the accessibility of At and SMT and, therefore, their photodegradation. In fact, there is no SMT degradation when using IEF-11 and the kinetics of degradation of At is ca. 11-fold lower than MIL-100(Ti) ( Table 1). Regarding the chemical nature of MOFs, there is not a direct relationship between the calculated band gap values (Fig. S1) and the photocatalytic capacity of these materials in the studied reaction. . Unlike its remarkable pharmaceuticals photodegradation capacity, MIL-100(Ti) can eliminate by adsorption only 13.5 ± 3.9% of At and 0 ± 3.9% of SMT after 5 h. Again, in a view of providing a comparison, the same experiment was performed using the Fe-based MIL-100(Fe) analogue, obtaining similar adsorption capacities for At (8.2 ± 5.5%) and SMT (14.2 ± 8.0%) than the MIL-100(Ti). The formation of interactions between the At and the MIL-100(Ti) is evidenced by Fourier transform infrared spectroscopy (FTIR) by comparing the spectra of free At to that of the empty and the At loaded material (At@MIL-100(Ti)). Specifically, there is a shift in the wavelengths of pure At (from 2964 and 2922 cm −1 to 2955 and 2925 cm −1 for At and At@MIL-100(Ti), respectively; see SI, Figure S5), characteristic of the ν(C-H) group of the C9 (near the ether group C9-O-benzene) 40 . In contrast, the MIL-125-NH 2 was able to adsorb up to 66.6 ± 1.1% of At and 50.2 ± 3.4% of SMT after 5 h. However, the release of the previously adsorbed EOCs was evidenced after 1 h, probably related with the degradation of the framework during the drug adsorption process (SI, Figure S2&S3). This is supported by the significant leaching of the linker (ca. 18% in both SMT and At adsorption after 5 h), confirmed by the similar FTIR spectra of the drug-loaded MIL-125-NH 2 and the free linker H 2 BDC-NH 2 (SI, Fig S6), and the amorphization of the MIL-125-NH 2 framework after the adsorption process (SI, Figs. S7&S8).
On the other hand, it is imperative to get fast degradation kinetics in order to achieve more efficient removal processes. The comparison of the At and SMT degradation kinetics has been performed through the fitting of the data to a second order kinetics according to Eq. (1) (see experimental section and SI, Figure S9). Although the data have also been fitted to a zero and first order kinetics, a better correlation was found using the second order. This is in agreement with previously reported photoactive MOFs and composites (i.e., MIL-125-NH 2 and AgNC@MIL-125-NH 2 in the degradation of SMT or methylene blue) 12 . The best degradation rate is obtained when using MIL-125-NH 2 in the At degradation, with a k value of 122,555 M −1 ·h −1 , which is ca. 2, 10 and 109fold higher than MUV-10(Ca), MIL-100(Ti), and IEF-11, respectively. In the case of SMT, the best degradation rate is obtained for MIL-100(Ti), with a k value of 112,013 M −1 ·h −1 , which is ca. 2, 5, and 23-fold higher than MIL-125-NH 2 , MIL-100 (Fe), and MUV-10(Ca), respectively. Finally, when evaluating the kinetics of the photocatalytic process using MIL-100(Ti) and MIL-125-NH 2 , the particle size and the external surface may also play important roles. It is generally accepted that smaller particles might favor the catalytic reactions. Tentatively, we can argue that the smaller MIL-125-NH 2 particles (ca. 240 nm with an estimated external surface of 225 mg 2 ·g −1  www.nature.com/scientificreports/ by t-plot method (p/p 0 from 0.3 to 0.6)) than MIL-100(Ti) (> 1 µm with an external surface of 195 mg 2 ·g −1 ) will favor the transport of EOCs and degradation products. Aside from the EOCs elimination capacity, the chemical stability of the framework is a limiting parameter in water decontamination processes. The point is to avoid an extra contamination of water due to the leaching of the MOFs constituents (e.g., ligands, metals). Therefore, and in contrast with the vast majority of reports on this topic, we have here considered the possible release of the MOF's building blocks. The chemical stability of a coordination network mainly depends on the strength of the metal to linker bonds, which can be estimated according to the hard and soft acids and bases (HSAB) principle 41 , and the competition with reactive species found in the solution. Thus, the release of the constitutive ligand was monitored by HPLC and the crystalline structure was checked by XRPD. At this point, it should be noted that the degradation of the frameworks was not evaluated via the quantification of the released metallic species in solution as, under the working conditions (contaminated tap water, pH = 8.2) and according to the Pourbaix diagram 42 , the vast majority of the degraded metallic species would be precipitated (i.e., TiO 2 ), underestimating the MOF degradation. Through the linker release, MOFs degradation could be also overestimated, as it can be adsorbed in the porosity of the framework (e.g., poorly activated/purified solids). However, we should rule out the release of any species that could be toxic, which in imperative for water decontamination. During the At and SMT photodegradation, the chemical stability of the framework in At or SMT-contaminated tap water decreased in the following order: (At) IEF-11 > MIL-100(Ti) > > MIL-125-NH 2 ~ MUV-10(Ca); and (SMT) IEF-11 > MIL-100 (Ti) > > MUV-10(Ca) ~ MIL-125-NH 2 ( Table 1). Note here that the stability ranking is very similar for At and SMT, ruling out an important effect of the drug nature on the MOF degradation. In addition, the XRPD patterns of the At-and SMT-containing MOFs evidenced that the At or SMT loading process does not alter the crystalline structure of MIL-100(Ti) and IEF-11, but there is an important peak broadening in the MUV-10(Ca) and MIL-125-NH 2 materials, consistent with a crystallinity loss (SI, Figure S7&S8). Remarkably, MIL-100(Ti) and IEF-11 show a high chemical stability under the working conditions with only ca. 3 and 0.7% degradation, respectively, after 5 h in contact with the contaminants' solutions.
Considering the above results, the most promising photocatalyst for the At and SMT removal in water is MIL-100(Ti), demonstrating not only an exceptionally high and fast EOCs degradation (100% in 2 and 4 h, respectively), but also a moderate matrix degradation (ca. 9%). This is particularly important considering that the median oral lethal dose (LD 50 ) for H 3 BTC is ca. 4 times lower than the one for SMT and At (in rats, LD 50 is 8.4, 2 and > 2 g·kg −1 for H 3 BTC, SMT and At). Therefore, the proposed photodegradation method is efficiently improving the water quality within a short time. The results on the photodegradation of At and SMT using MIL-100(Ti) are on the range or even overpass the results obtained with other MOFs, MOF composites or other materials (SI , Table S2).
At this point, in an attempt to rationalize the complex process involved in the At and SMT photodegradation using MIL-100(Ti), we have explored the photocatalytic performance of the isostructural iron analogue MIL-100(Fe) under equal conditions. It should be pointed that even the different band gap values of the Ti and Fe based MIL-100 materials (3.48 and 2.73 eV, respectively, SI, Figure S1), both suspensions were irradiated in all the UV-vis range. As expected, the Ti-based MIL-100 is more efficient than its Fe counterpart, with a 100% and ca. 65% of At and SMT degradation after 5 h-irradiation, evidencing the crucial role of the titanium trimeric clusters. When comparing the kinetic of the process (Table 1), the degradation rates of At and SMT by MIL-100(Ti) is ca. 49 and 4.5-fold higher than the Fe isostructural MOF. Both materials are chemically stable under the studied conditions, with only ca. 10 and 1% of MIL-100(Fe) degradation in At and SMT solutions, respectively. However, in the case of MIL-100(Fe), the degradation of the framework seems to be affected by the nature of the contaminant, being favored in the presence of At. The amide of At may preferentially interact with the Fe metal sites than with the Ti ones (more oxophilic). Finally, the accessible porosity of the framework is not a determining factor when comparing the Fe and Ti-based MIL-100 materials. Although the accessible porosity of MIL-100(Fe) is double than the one of MIL-100(Ti) (SI, Table S1), this last material is the most effective in At and SMT degradation.
Photodegradation products using MIL-100(Ti). The hazard of these EOCs does not only relay on their concentration or toxicity, but also their metabolites or degradation products, which can sometimes be more harmful than the parent compounds 43 . The degradation products of At and SMT using MIL-100(Ti) were thus independently analyzed. Previous studies have described the photochemical behavior of At and SMT, determining that the degradation occurs through the cleavage at various positions ( Figure S10) 44 . The identification of the photodegradation products of At and SMT formed after 5 h-irradiation of the At@MIL-100(Ti) and SMT@MIL-100(Ti) systems in aqueous medium was carried out using UHPLC/MS, supported with fragmentation patterns obtained from MS/MS experiments. Although the determination of the EOCs degradation pathway is out of the scope of this work, we have successfully identified some intermediates deduced from their estimated molecular weight, allowing to assess the potential toxicity of the resulting products.
Particularly for At, cleavage of the side chain and the addition of the hydroxyl group to the parent compound were found to be the two main degradation pathways (Figures S10&S11). Thus, the fragment ion m/z 134 (3-(isopropyl)propane-1,2-diol) was attributed to the product from the chain cleavage, and the ions m/z 167 2-(2,4-dihydroxyphenyl)acetamide and 2-(3,4-dihydroxyphenyl)acetamide to the chain cleavage and oxidation. These photodegradation pathways and intermediates have been frequently reported in the photodegradation of At [45][46][47] .
On the other hand, in the SMT photodegradation study, the fragment ion m/z 216.7 (N-(4,6-dimethylpyrimidin-2-yl)benzene-1,4-diamine) was attributed to the product from SO 2 extrusion, a phenomenon frequently shown in sulfonamides (Figs. S10&S12) 48 . The attack of a hydroxyl radical at the C-N bond of the benzene ring  49 . Importantly, regarding the potential toxicity of the degradation products, neither of the intermediated formed through At and SMT photodegradation exhibit acute toxicity 45 , supporting then the significant improvement of the resulting water quality.
Combined EOCs photodegradation using MIL-100(Ti). In real water environments, physicochemical conditions are not static (e.g., presence of more than one pollutant with a different range of concentrations, or the pH of natural waters are normally found between 5 and 8) 50,51 . Therefore, the target of an efficient photocatalyst should be the elimination of most of the EOCs present in this water in a range of different conditions (contaminants and catalyst concentration and contaminated water pH). In this context, first the At and SMT removal by MIL-100(Ti) was simultaneously investigated using a mixture of both contaminants in tap water (initial pH = 8.2). In this sense and to the best of our knowledge, there are no reported examples of the combined photodegradation of water EOCs using MOFs, but only the evaluation of their combined adsorption 52 . Remarkably, when both pollutants are present in solution, the time required to fully degrade the SMT is similar to the single SMT removal (100% of the SMT is removed in only 4 h, Fig. 3). In contrast, the At elimination is slowed down, and the time required to remove 100% of the At is doubled (from 2 to 4 h). The kinetics of the process is modified in both reactions, being the degradation rate reduced up to 4.5 and 2.4-fold for At and SMT, respectively ( Table 2). This could be explained by the competitive degradation of SMT and At, where the SMT is favored over the At photodegradation. Regarding the MOF stability, in presence of both EOCs, the leaching of the H 3 BTC linker is maintained, indicating the potential of the MIL-100(Ti) in the photodegradation of EOCs in water. In a further step to real conditions, other factors such as initial concentration of At and SMT, catalyst amount, and pH, were analyzed. The effect of the initial concentration of contaminants was studied using different At and SMT initial concentrations (from C 0 = 35 and 5 ppm to 17.5 and 2.5 ppm, respectively). MIL-100(Ti) degraded most of the SMT (95%) at low initial concentration, while the degradation efficiency of At decreased from 100% (C 0 = 35 ppm) to 15% (C 0 = 17.5 ppm) after 5 h irradiation. This phenomenon suggests that MIL-100(Ti) efficiently increases with EOCs concentration, which has great significance in more dangerous (toxic) environments. In agreement, no changes in the crystallinity or MIL-100(Ti) particles morphology are observed (SI, Figure S12).  www.nature.com/scientificreports/ On the other hand, when the amount of catalyst is reduced by half (from 4 to 2 mg), a high SMT removal (ca. 83%) is achieved, while the At removal capacity is considerably reduced (only ca. 44% in 5 h). In terms of MOF stability, the XRPD patterns showed that changes in contaminants concentration do not affect the crystallinity of MIL-100(Ti), while an important amorphization is observed when less amount of MIL-100(Ti) is used (SI, Figure S12). These results are supported by FESEM images, with important morphological changes in MIL-100(Ti) when the amount of MOFs is halved.
Finally, the effect of pH in At and SMT degradation was studied, by changing from an initial pH of contaminated water from 8.2 to 6.4 and 5.5. Under acidic conditions (pH = 6.5 and 5.5), the SMT elimination levels are maintained (ca. 90 and 91% of SMT degradation, respectively), while the At degradation capacity is strongly affected (only 27 and 9% of At is degraded in 5 h, respectively). Considering the pk a of SMT (pK a1 = 2.65-aromatic amine; pK a2 = 7.65-sulfonamide) and the pka of At (9.6-amine), SMT is predominantly neutral (pH = 6.4 and 5.5) or protonated (pH = 8.2), while At is always protonated (pH = 5.5-8.2). Therefore, the protonation or deprotonation of the EOCs will not strongly affect the intermolecular electrostatic attraction between EOCs and MIL-100(Ti). However, considering that one of the interactions of the At with the MOF is through the central O of the At (according to FTIR, see above), it could be hypothesized that, as the attraction between the drug and the framework is stronger when the initial pH is higher, leading into a higher photocatalytic performance. The XRPD patterns demonstrated an amorphization under acidic conditions (SI, Figure S13). From the practical point of view, and although an optimization of the process is needed, we can conclude that the optimal working conditions for MIL-100(Ti) in SMT and At degradation are high EOCs concentrations (35 and 5 ppm, respectively), 4 mg of catalyst and alkaline waters. -100(Ti). The efficiency of a catalyst is significantly enhanced if the material can be reused for several photodegradation cycles. After 5 h-irradiation, MIL-100(Ti) was recovered from the treated water by centrifugation, and resuspended in fresh contaminated water (mixture of contaminants). Upon 5 photodegradation cycles, MIL-100(Ti) efficiently removed SMT and At without a significant decrease on the efficiency (Fig. 4). Note here however that, upon the first and second cycles, an important peak broadening, consistent with a partial amorphization, is observed in the XRPD patterns (SI, Figure S14), leading to a completely amorphous solid after the third cycle. In contrast, the chemical integrity of MIL-100(Ti) is kept after the 5 cycles, with only 5% of the linker released. One could suggest that upon photocatalytic cycles, the chemical composition of the MIL-100(Ti) is almost kept, while the creation of defects leads to the loss of the long-range order, while improving the quality of water.

Conclusions
The screening of 4 robust Ti-MOFs for the removal of EOCs in tap water has allowed the selection of an extremely efficient photocatalyst, the mesoporous titanium trimesate MIL-100(Ti). Here, we present the successful photodegradation of the challenging EOCs, SMT and At, by this material, able to efficiently eliminate SMT and At (100% removal at 2 and 4 h, respectively) from tap water without an important chemical degradation. In addition, the generation of lower potential toxic products upon photodegradation supports the significant improvement of the quality of water. Further, when working with a contaminants mixture, the ability of MIL-100(Ti) to remove SMT is kept intact, while the At photodegradation is slowed-down, as a consequence of the drug competition. Upon 5 photodegradation cycles, MIL-100(Ti) efficiently removes both SMT and At, envisioning the future real www.nature.com/scientificreports/ application of this MOF on the removal of SMT and At as well as other widespread EOCs in environmental remediation.

Methods
All reactants were commercially obtained and used without further purification. The synthesis of starting materials was performed following similar synthetic procedures as previously reported (see below). 33 . Ti 6 (7.2 mg, 24 mmol of Ti) and trimesic acid (H 3 BTC, 25.0 mg, 120 mmol) were dispersed in 3 mL of a mixture of acetonitrile:tetrahydrofuran (ACN:THF, 3:1, v/v%) in a glass vial. Subsequently, 250 mL of acetic acid (180 equiv.) were added, and the mixture was sonicated to get a homogeneous suspension. The vial was placed in the oven at 160 ºC for 48 h. After cooling down to room temperature (RT), the white microcrystalline powder was recovered by centrifugation at 5000 rpm for 2 min, rinsed with fresh N,N-dimethylformamide (DMF) and methanol (MeOH) and further purified by Soxhlet extraction with hot ethanol (EtOH) or MeOH for 8 h. The solid was then allowed to dry under vacuum at RT. The as-synthesized dried product was dispersed at RT in DMF under stirring overnight (on, 100 mL of DMF per g of product). Then, the same procedure was repeated once using MeOH instead of DMF for 4 h. 36 . Finely ground squaric acid (H 2 SQ, 255 mg, 2.24 mmol) was suspended in 8.2 mL of isopropanol in a 25 mL round-bottom flask, magnetically stirred for 5 min at RT and sonicated in an ultrasound bath for another 5 min. Then, glacial acetic acid (6.4 mL, 111.9 mmol) was added and sonicated again for 15 min. Then, titanium(IV) butoxide (762 μL, 2.24 mmol) was slowly added to the previous solution under stirring and then, heated at 50 °C for 15 min. The resulting orange suspension was transferred into a 23 mL Teflon-lined steel autoclave, sealed and heated at 120 °C for 48 h with heating and cooling ramp of 1.5 °C·min −1 . The resulting orange-brown solid was filtered under vacuum, washed with isopropanol and dried in open air at RT. Finally, the sample was heated at 200 °C for 24 h in order to remove the remaining acetate moieties from the surface of the solid. Experimental techniques. Fourier transform infrared spectroscopy (FTIR) studies were recorded using a Nicolet 6700 FTIR thermo scientific spectrometer in the 400-4000 cm −1 region. X-ray powder diffraction (XRPD) patterns of all samples were collected in an Empyream PANALYTICAL diffractometer, equipped with a PIXcel3D detector and a copper radiation source (Cu Kα, λ = 1.5406 Å), operating at 45 kV and 40 mA. Profiles were generally collected in the 3º < 2θ < 35º range with a typical step size of 0.013º and 40 s of acquisition. N 2 isotherms were obtained at 77 K using a TriStar II Plus Instruments. Before the measurement, samples were evacuated under vacuum at 150 ºC 16 h for MIL-100(Ti) and MUV-10(Ca), 200 °C 16 h for MIL-125-NH 2 , and 130 ºC 3 h for MIL-100(Fe). Specific surface area was determined by applying Brunauer, Emmett & Teller equation (BET) in the relative pressure interval p/p 0 = 0.01-0.3 (being p 0 the saturation pressure). External surface area was calculated by t-plot method in the relative pressure interval p/p 0 = 0.3-0.6). FESEM (Field Emission Scanning Microscope) JEOL JSM-7900F was used to obtain high resolution images of nanomaterials with magnifications from 20 to 1,000,000x and secondary electrons detector.

Synthesis of IEF-11 or [Ti 2 O 3 (SQ)]
Different organic molecules were analyzed by HPLC: the amount of degraded sulfamethazine (SMT) and atenolol (At), as well as the released corresponding linkers (H 2 BDC-NH 2 or H 3 BTC), was determined using a reversed phase HPLC Jasco LC-4000 series system, equipped with a photodiode array (PDA) detector MD-4015 Adsorption and/or photocatalytic degradation of SMT and/or At from water. The adsorption/ photocatalytic activity of Ti-MOFs was evaluated in terms of elimination of both EOCs, SMT and At. In a typical experiment, 4 mg of MOF (MIL-100(Ti or Fe), MUV-10(Ca), MIL-125-NH 2 or IEF-11) were suspended in 4 mL of a SMT or At tap-aqueous solution (5 ppm 54 , and 35 ppm 22,23 , respectively; according with the concentration of SMT and At found in the environment). Adsorption/photodegradation reactions were performed under magnetic stirring. At certain intervals (0.25, 0.5, 1, 2, 4, and 5 h), an aliquot of 100 μL was collected by centrifugation for HPLC analysis (SMT, At and the corresponding ligand). All experiments were performed at least in triplicate to ensure statistically reliable results. The crystallinity of the remaining solids was analyzed by XRPD. First of all, the stability of an aqueous solution of SMT and At was studied under UV-vis light in absence of the photocatalyst. It was verified that SMT and At were not degraded (after 5 h) under UV-vis light irradiation.
SMT and At photodegradation products: Particularly in the At and SMT photodegradation studies, after 5 h of UV-vis irradiation, an aliquot was analyzed by mass quadrupole spectrometry coupled to ultra-high performance liquid chromatography (UHPLC) to determine the final products of the photodegradation. Standard samples of SMT and At were measured to deduce through comparison the mass parents obtained.
The photodegradation experiments were performed in a glass photoreactor equipped with a 300 W Xe lamp (Oriel Instrument OPSA500) under open air at RT, with the samples stirred and placed at a fixed distance of 21 cm from the irradiation source. It must be pointed that prior to irradiation it is not necessary to stir the suspension until the adsorption-desorption equilibrium is reached.
Although the selected Ti-based MOFs show a different experimental band gap (3.48, 2.73, 3.63, 2.53, and 2.40 eV for MIL-100(Ti), MIL-100(Fe), MUV-10(Ca), MIL-125-NH 2 , and IEF-11, respectively; values obtained by the Tauc Plot, Supporting information-SI Figure S1) 55 , we have irradiated all samples under the full UV-vis spectra. It should be noted that the use of a glass photoreactor may minimize the UV irradiation.
Combined At and SMT adsorption and/or photodegradation capacity of MIL-100(Ti): In an attempt to reproduce real water conditions, the same procedure was performed in a mixture of At and SMT in tap water. 4 mg of MIL-100(Ti) were suspended in 4 mL of a mixture of SMT (5 ppm) and At (35 ppm) tap-aqueous solution. Adsorption/photodegradation reactions were performed under stirring. At certain intervals (0.25, 0.5, 1, 2, 4, and 5 h), an aliquot of 100 μL was collected by centrifugation for HPLC analysis (SMT, At and H 3 BTC ligand). If necessary, pH was adjusted with diluted solutions NaOH and HCl. All experiments were performed at least in triplicate to ensure statistically reliable results. The crystallinity of all the remaining solids was analyzed by XRPD.
Photodegradation kinetics: To shed some light on the At and SMT degradation kinetics and to gain further understanding on the involved mechanism, the first 2 h of At and SMT degradation were fitted to a second order kinetics according to Eq. (1), where [A] and [A] 0 is the remaining concentration of contaminant (M, mol·L −1 ) at the time t (h) and the initial contaminant concentration, respectively, and k is the second order kinetic constant (M −1 ·h −1 ).

Recyclability of MIL-100(Ti):
The recyclability of MIL-100(Ti) was studied repeating the same procedure above described. 4 mg of MIL-100(Ti) were suspended in 4 mL of a mixture of At (35 ppm) and SMT (5 ppm) tap-aqueous solution under UV-vis light irradiation (considering the solubility of H 3 BTC (26.3 mg·ml −1 ), always working under sink conditions). After 5 h, the sample was centrifuged, an aliquot of 100 μL was collected for HPLC analysis (At, SMT and H 3 BTC quantification), and the solid was resuspended again in a fresh At and SMT aqueous solution for 24 h. This process was repeated for 5 cycles. (1)